Reported numbers of SARS-CoV-2 infections by age group (5–11, 12–17, 18–49, 50–64, ≥65 years of age) from 22 U.S. jurisdictions (AR, AZ, CA, CO, CT, DC, FL, GA, IN, KS, MI, MA, MN, NC, NE, NJ, NM, NYC, PHL, TN, UT, WI ); ~53% of the U.S. population) with routine linkages between COVID-19 case surveillance and immunization information system (IIS) data reported to CDC during January 16, 2022 – May 28, 2022.
Vaccine administration (coverage) data reported to CDC were aggregated by U.S. reporting jurisdiction, MMWR week of vaccination (≥14 days after completing the primary vaccine series), FDA-approved vaccine products, and age group (5–11, 12–17, 18–49, 50–64, ≥65 years).
Vaccination status: A person vaccinated with at least a primary series had SARS-CoV-2 RNA or antigen detected on a respiratory specimen collected ≥14 days after verifiably completing BNT162b2 (Pfizer-BioNTech) primary series. An unvaccinated person had SARS-CoV-2 RNA or antigen detected on a respiratory specimen and has not been verified to have received COVID-19 vaccine. Excluded were partially vaccinated people who received at least one FDA-authorized vaccine dose but did not complete a primary series ≥14 days before collection of a specimen where SARS-CoV-2 RNA or antigen was detected.
To estimate the number of unvaccinated persons in each MMWR week, the 2019 U.S. Census population estimates by jurisdiction and age group were used (except for California, where State Department of Finance 2021 population projections were determined to be more accurate). The number of unvaccinated persons each MMWR week was estimated by subtracting the cumulative number of vaccinated (all products) and partially vaccinated persons (all products) from the respective population totals for each jurisdiction and age group.
Continuity correction: A continuity correction has been applied to the denominators by capping the percent population coverage at 95%. To do this, we assumed that at least 5% of each age group would always be unvaccinated in each jurisdiction. Adding this correction ensures that there is always a reasonable denominator for the unvaccinated population that would prevent rates from growing unrealistically large due to potential overestimates of vaccination coverage.